Bleeding or risk of bleeding risk with increasing fibrinolysis both generalized (bleeding during surgery and in the postoperative period, postpartum haemorrhage, manual separation of placenta, placental chorionic, bleeding during pregnancy, malignancy, pancreatic and prostate cancer, haemophilia, haemorrhagic complications in fibrinolytic therapy, thrombocytopenic purpura, leukaemia, liver diseases, previous therapy with streptokinase) and local (uterine, nasal, pulmonary, gastrointestinal bleeding, haematuria, bleeding after prostatectomy, cervical conisation due to carcinoma, tooth extraction in patients with haemorrhagic diathesis). Surgeries on the bladder. Surgical manipulations in systemic inflammatory response (sepsis, peritonitis, necrotizing pancreatitis, severe and moderate gestational toxicosis, shock of different aethiology and other critical states).

Treating of dermatoses sensitive to corticosteroids in the presence (or suspected) bacterial and / or fungal infections caused by sensitive to  a drug  micro- organisms.

Dermatoses sensitive to glucocorticosteroid therapy with suspected to complications or complications from secondary infections caused by susceptible microorganisms to the drug. Treatment of mycosis stop, jock itch and trihofitii smooth skin caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, candidiasis caused by Candida albicans, and tinea versicolor caused by Malassezia furfur (Pityrosporum obliculare).

An additional source of amino acid beta-alanine, isoflavonoids and terpenes in order to normalize the functional state at nervous system during psycho-emotional and vegetative-vascular disorders (irritability, depressive condition and mood swings, sleep disturbances, hot flashes, sweating above normal) for women in premenopausal and menopause syndrome.

Venous insufficiency; pre-varicose and varicose syndrome; superficial thrombophlebitis, phlebitis and postphlebitic states; combined therapy of hemorrhoids; pain and swelling syndrome in cases of injuries and varicose veins; calf cramps.

Treatment of acute uncomplicated infections of the lower urinary tract caused by susceptible to fosfomycin microorganisms, in men, in girls aged 12 years and women. Prophylaxis during diagnostic procedures and surgical interventions in adult patients.

Acute and chronic infections of the urinary tract and kidneys (cystitis and pyelonephritis), urolithiasis and uriatic diathesis (prophylaxis of calculi formation after their removal), chronic cholecystitis (including calculous), biliary dyskinesia, cholelithiasis.

Acute and chronic infections in urinary tract and kidneys (cystitis and pyelonephritis); urolithiasis and lithic diathesis (prevention of calculi formation after their removal); chronic cholecystitis (including calculous cholecystitis), biliary dyskinesia, gallstone disease.